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Buy Ketamine HCL Online

Buy Ketamine HCL Online

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Buy Ketamine HCL Online (also known as ket, K, special K, kitty, horse/dog/vet tranquilizer, and others) is a dissociative substance of the arylcyclohexylamine class. Ketamine is chemically related to phencyclidine (PCP) and methoxetamine (MXE). Like other dissociatives, it acts by blocking NMDA receptors in the brain.

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Description

Buy Ketamine HCL Online (also known as ket, K, special K, kitty, horse/dog/vet tranquilizer, and others) is a dissociative substance of the arylcyclohexylamine class. Ketamine is chemically related to phencyclidine (PCP) and methoxetamine (MXE). Like other dissociatives, it acts by blocking NMDA receptors in the brain.

 

Buy Ketamine HCL Online was developed in 1963 by Parke-Davis Laboratories as part of an effort to find a replacement for the surgical anesthetic phencyclidine (PCP). It became available by prescription in 1969 under the name Ketalar. Today, ketamine is widely used in human and veterinary medicine, primarily for general anesthesia for surgical procedures. It is also used illicitly as a recreational substance and is associated with the clubbing and raving scenes.

Typical effects of ketamine include sedation, hallucinations, and dissociation, which is characterized by perceptual distortions and feelings of detachment from the environment and ones self. The effects of ketamine are similar to those of PCP but ketamine is much less potent and its effects are of much shorter duration. The effects of ketamine are highly dose dependent. At lower doses, users report disinhibition and relaxation effects similar to those of alcohol. Higher doses exceeding a certain threshold are capable of inducing experiences described as out-of-body or near-death experiences.

It is highly advised to use harm reduction practices if using this substance.

History and culture

Buy Ketamine HCL Online began as a veterinary anaesthetic when it was patented in Belgium in 1963. After being patented by Parke-Davis for human and animal use in 1966, ketamine became available by prescription in 1969 in the form of ketamine hydrochloride, under the name of Ketalar. It was officially approved for human consumption by the United States Food and Drug Administration in 1970 and, because of its sympathomimetic properties and its wide margin of safety, was administered as a field anaesthetic to soldiers during the Vietnam war.

Ketamine is on the World Health Organization’s “Essential Drugs List”, a list of the safest and most effective drugs needed in a modern health system.

Chemistry

Buy Ketamine HCL Online, or (RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone, is a member of the arylcyclohexylamine chemical class. Arylcyclohexylamines are named for their chemical structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Ketamine is comprised of a phenyl ring with a chlorine substituent at R2 bonded to a cyclohexane ring substituted with an -Oxo group (cyclohexanone). An amino methyl chain (-N-CH3) is bound to the same location (R1) of the cyclohexanone ring.

Ketamine is a chiral molecule and is typically produced as a racemate. Enantiopure versions such as esketamine (S-ketamine) and arketamine (R-ketamine) are sometimes used.

Pharmacology

Ketamine acts as a non-competitive antagonist of the NMDA receptor, an ionotropic glutamate receptor. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the notorious state known as the “K-hole”.

At high, fully anesthetic level doses, ketamine has also been found to bind to μ-opioid receptors type 2 in cultured human neuroblastoma cells without agonist activity and to sigma receptors in rats. Also, ketamine interacts with muscarinic receptors, descending monoaminergic pain pathways and voltage-gated calcium channels. At subanesthetic and fully anesthetic doses, ketamine has been found to block serotonin depletion in the brain by inhibiting 5-HT receptors rather than through monoamine oxidase inhibition.

Additional information

Ketamine HCL

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