Description

Buy Mexedrone Online (3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one) is a putative stimulant and possible euphoriant of the cathinone chemical class with a potency of roughly 1/10th of that of mephedrone.

This compound has little to no history of human usage prior to its release in August 2015 as a newly available grey area research chemical. It has been primarily marketed as a legal alternative to mephedrone although anecdotal reports seem to universally suggest that it is largely inferior in its recreational effects due to its weaker potency, lack of stimulation and euphoria.

Chemistry

Buy Mexedrone Online, or 3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one, is a synthetic molecule of the cathinone family. Cathinones are structurally similar to amphetamines. They contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. Amphetamines and cathinones are alpha-methylated phenethylamines. Cathinones contain an additional ketone group bonded at R1.

Mexedrone contains additional methyl substitutions at RN (similar to MDMA and methamphetamine) and R4 of its phenyl ring. Mexedrone is named for the methoxy group (C3O-) bound to the methyl group located at Rα.

Pharmacology

Buy Mexedrone Online acts as a releasing agent of serotonin and a reuptake inhibitor for monoamine neurotransmitters serotonin, dopamine and noradrenaline . Despite its chemical similarity to mephedrone, it lacks the dopamine and noradrenaline releasing properties, and is approximately 10-20x weaker in its reuptake inhibiting and serotonin releasing properties.

This increase in neurotransmitters provides an explanation for the euphoric and anecdotal stimulating effects induced by this experience. The serotonergic activity with lack of significant dopaminergic and noradrenergic activity is similar to that of MDAI and consistent with usage reports that often state that mexedrone is more sedating than stimulating.

Due to the much lower potency (1/7 to 1/20th at different monoamine transporters) compared to mephedrone, considerably higher doses are required to achieve noticeable effects.
Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.